Ibicuruzwa
2,4-Diamino-6-hydroxypyrimidine
Hydroxypyrimidine Ibiranga imiti
| Ingingo yo gushonga | 285-286 ° C (Ukuboza) (lit.) |
| Ingingo yo guteka | 234.22 ° C (igereranya) |
| ubucucike | 1.3659 (igereranya) |
| indangagaciro | 1.7990 (igereranya) |
| ububiko bwa temp. | Komeza ahantu hijimye, Inert ikirere, Ubushyuhe bwicyumba |
| gukemura | DMSO (Buhoro), Methanol (Buhoro) |
| pka | 10.61 ± 0.50 (Byahanuwe) |
| ifishi | Ifu nziza ya Crystalline |
| ibara | Cyera |
| Yumva | Umucyo |
| Merk | 14.2981 |
| BRN | 125006 |
| InChIKey | SWELIMKTDYHAOY-UHFFFAOYSA-N |
| CAS DataBase Reba | 56-06-4 (CAS DataBase Reba) |
| Ubumenyi bwa NIST | 4 (1H) -pyrimidinone, 2,6-diamino- (56-06-4) |
| Sisitemu yo Kwiyandikisha Ibintu | 2,6-Diamino-4 (1H) -pyrimidinone (56-06-4) |
Hydroxypyrimidine Ibisobanuro
2,4-Diamino-6-hydroxypyrimidine ni imiti ivanze na molekile ya C4H6N4O.Nibintu kama kama mumuryango wa pyrimidine.Urusange rufite imiterere yimpeta ya pyrimidine, amatsinda abiri ya amino (NH2) ahujwe kumwanya wa 2 na 4-imyanya, naho hydroxyl group (OH) ihujwe kumwanya wa 6.Imiterere yimiti irashobora kugaragazwa nka: Amoniya ||H - C - C - C - N - C - C - NH2 || yewe 2,4-Diamino-6-hydroxypyrimidine ifite porogaramu zitandukanye mu nganda zimiti.Nibihe byingenzi muguhuza imiti myinshi, harimo imiti igabanya ubukana na antitumor.Ikoreshwa kandi mugukora nucleotide nyinshi ikoreshwa mubushakashatsi bwa farumasi.
Usibye gukoresha imiti, 2,4-diamino-6-hydroxypyrimidine nayo ikoreshwa nkibigize ubuhinzi-mwimerere.Nibintu byingenzi muguhuza ibimera bikura hamwe na fungicide.Ni ngombwa cyane gukurikiza protocole yumutekano ikwiye mugihe ukoresheje 2,4-diamino-6-hydroxypyrimidine.Kubera ko ishyirwa mubikorwa nkimiti itera imiti, igomba gukoreshwa neza kandi ibikoresho bihagije byo kurinda umuntu bigomba kwambara kugirango birinde guhura.
Muri make, 2,4-diamino-6-hydroxypyrimidine nuruvange kama hamwe nibisabwa mubikorwa bya farumasi nubuhinzi.Imiterere yimiti ituma igira akamaro nkigihe gito muguhuza imiti nubuvuzi bukura.
Amakuru yumutekano
| Kode ya Hazard | Xi |
| Ibisobanuro | 36/37/38 |
| Amatangazo yumutekano | 22-24 / 25-36-26 |
| WGK Ubudage | 3 |
| Icyitonderwa | Kurakara |
| TSCA | Yego |
| Kode ya HS | 29335995 |
Hydroxypyrimidine Ikoreshwa na Synthesis
| Ibisobanuro | 2,4-Diamino-6-hydroxypyrimidine (DAHP) ni ihitamo, ryihariye rya GTP cyclohydrolase I, igipimo kigabanya intambwe ya de novo pterin synthesis.Muri selile HUVEC, IC50kubuza BH4biosynthesis ni 0.3 mM.DAHP irashobora gukoreshwa muguhagarika neza NTA musaruro muburyo butandukanye. |
| Ibikoresho bya Shimi | Umweru |
| Gukoresha | 2,4-Diamino-6-hydroxypyrimidine (DAHP) ni ihitamo, ryihariye rya GTP cyclohydrolase I, igipimo kigabanya intambwe ya de novo pterin synthesis.Muri selile HUVEC, IC50 yo kubuza BH4 biosynthesis ni 0.3 mM.DAHP irashobora gukoreshwa muguhagarika neza NTA musaruro muburyo butandukanye. [Cayman Chemical] |
| Gukoresha | Ihagarara ku ntangiriro ya cascade ya enzyme-catisale itangirana na karubone ya karubone irindwi ikarangirana na aromatic amino acide fenylalanine, tirozine, na tryptophan |
| Gukoresha | 2,4-Diamino-6-hydroxypyrimidine (cas # 56-06-4) nuruvange rufite akamaro muri synthesis organique. |
| Uburyo bwo kweza | Isubiramo kuva H2O.[Beilstein 25 III / IV 3642.] |
