Di-tert-butyl dicarbonate

Ibisobanuro bigufi:

Izina RY'IGICURUZWA:Di-tert-butyl dicarbonate

Synonyme:(BOC) 2O; (BOC) 2O FLUKA; BOC; BOC ANHYDRIDE; tert-butyldicarbonate;

URUBANZA:24424-99-5

MF:C10H18O5

MW:218.25

EINECS:246-240-1

Ibyiciro by'ibicuruzwa:Imiti ya Farumasi; Gutangira Ibikoresho Byoroheje & Intermediates; Ibikomoka kuri Acide Amino; Ibinyabuzima; N-Kurinda Reagents; Biochemie; Peptide Synthesis; Kurinda & Derivatisation Reagents (kuri Synthesis); Urutonde rwa acide ya Boc-Amino; Reagents zitandukanye; DIBOC; 1H-Inden-1-ol; bc0001; 24424-99-5

Idosiye ya Mol:24424-99-5.mol

Ohereza imeri kuri twe

Ibicuruzwa birambuye

Ibicuruzwa

Di-tert-butyl dicarbonate Ibiranga imiti

Ingingo yo gushonga	23 ° C (lit.)
Ingingo yo guteka	56-57 ° C / 0.5 mmHg (lit.)
ubucucike	0,95 g / mL kuri 25 ° C (lit.)
umuvuduko w'umwuka	3.85Pa kuri 25 ℃
indangagaciro	n20 / D 1.409 (lit.)
Fp	99 ° F.
ububiko bwa temp.	2-8 ° C.
ifishi	Gushonga Hasi ya Crystalline Ikomeye
ibara	Cyera
Uburemere bwihariye	0.950
Amazi meza	Ntibisanzwe hamwe na decalin, toluene, tetrachloride ya karubone, tetrahydrofuran, dioxane, alcool, acetone, acetonitrile na dimethylformamide.Ntibishoboka n'amazi.
Yumva	Ubushuhe
BRN	1911173
InChIKey	DYHSDKLCOJIUFX-UHFFFAOYSA-N
LogP	1.87 kuri 25 ℃
CAS DataBase Reba	24424-99-5 (CAS DataBase Yerekana)
Sisitemu yo Kwiyandikisha Ibintu	Acide Dicarbonique, bis (1,1-dimethylethyl) ester (24424-99-5)

Amakuru yumutekano

Kode ya Hazard	T +, T, F, Xi, F +
Ibisobanuro	11-19-26-36 / 37 / 38-43-10-40
Amatangazo yumutekano	16-26-28-36 / 37-45-7 / 9-37 / 39-24-36 / 37 / 39-33
RIDADR	UN 2929 6.1 / PG 1
WGK Ubudage	3
RTECS	HT0230000
F	4.4-10-21
Ubushyuhe bwa Autoignition	460 ° C.
Icyitonderwa	Umuriro / Kurakara / Uburozi Cyane
TSCA	Yego
HazardClass	6.1
Gupakira	I
Kode ya HS	29209010
Uburozi	LD50 kumunwa murukwavu:> 5000 mg / kg LD50 Urukwavu rwa dermal> 2000 mg / kg

Di-tert-butyl dicarbonate Ikoreshwa na Synthesis

Ibikoresho bya Shimi	Di-tert-butyl dicarbonate (BOC Anhydride, DiBOC) ni ibara ritagira ibara ryera kugeza ryera ry'umuhondo, misa ikomeye cyangwa amazi meza.Irashonga hafi yubushyuhe bwicyumba (mp = 23 ° C).Ntabwo ibora kuriyi cyangwa nubushyuhe bwo hejuru.Kurugero, mubisanzwe bisukurwa no gusibanganya munsi yumuvuduko ukabije kubushyuhe bugera kuri 65 ° C.Ku bushyuhe bwo hejuru izabora isobutene, inzoga ya t-butyl na dioxyde de carbone.
Gukoresha	Di-tert-butyl dicarbonate (Boc2O) ni reagent ikoreshwa cyane mugutangiza amatsinda yo kurinda peptide.Ifite uruhare runini mugutegura 6-acetyl-1,2,3,4-tetrahydropyridine ikora na 2-piperidone.Ikora nkitsinda ririnda rikoreshwa mugice cya peptide ikomeye.
Kwitegura	Gutegura Di-tert-butyl dicarbonate nuburyo bukurikira: Kumuti wumunyu wa sodium wa monoester wongeyeho 2g ya N, N-dimethylformamide, 1g ya pyridine, 1g ya triethylamine, Gukonja kuri -5 ~ 0 ° C, 60g diphosgene yari buhoro buhoro wongeyeho ibitonyanga muri 1.5h ibitonyanga byongeweho byuzuye, bishyushya ubushyuhe bwicyumba (25 ° C), byashyizwe kuri 2h, reaction yemerewe guhagarara nyuma yo kuyungurura, gukaraba igisubizo kama.Yumye hamwe na sulfate ya anhidrous magnesium sulfate, umusemburo watandukanijwe numuvuduko wikirere kugirango utange ibicuruzwa bitavanze 65 ~ 70g.Nyuma yo gukonjesha no gutegera, 57-60g ya di-tert-butyl dicarbonate yabonetse mu musaruro wa 60-63%.
Ibisobanuro	ChEBI: Di-tert-butyl dicarbonate ni acyclic carboxylic anhydride.Ifitanye isano na aside ya dicarubone.
Ibisubizo	Imyitwarire ya aniline yasimbuwe na Boc2O imbere ya stoichiometric ya 4-dimethylaminopyridine (DMAP) mumashanyarazi ya inert (acetonitrile, dichloromethane, Ethyl acetate, tetrahydrofuran, toluene) mubushyuhe bwicyumba biganisha kuri aryl isocyanates hafi 10. min. Di-tert-butyl dicarbonate na 4- (dimethylamino) pyridine yasubiwemo.Imyitwarire yabo hamwe na amine na alcool
Ibisobanuro rusange	Di-tert-butyl dicarbonate (Boc₂O) ni reagent ikoreshwa cyane cyane mugutangiza itsinda ririnda Boc kurinda amine imikorere.Ikoreshwa kandi nkibikoresho byo kubura umwuma mubisubizo bimwe na bimwe kama, cyane hamwe na acide karubike, amatsinda amwe ya hydroxyl, cyangwa hamwe na nitroalkane yibanze.
Hazard	Umujinya ushobora gutera igikomere gikomeye cyamaso;Birashobora gutera uruhu;Uburozi bukabije no guhumeka
Gutwikwa no guturika	Umuriro
Uburyo bwo kweza	Gushonga ester ushyushya kuri ~ 35o, hanyuma ukayungurura mu cyuho.Niba IR na NMR (18. no kuyitandukanya mu cyuho.[Papa n'abandi.Org Synth 57 45 1977, Keller n'abandi.Org Synth 63 160 1985, Grehn n'abandi.Angew Chem 97 519 1985.] FLAMMABLE.