Ibicuruzwa
DicyclopexylcarboDiimage; CYA No: 538-75-0
Synonyme: DCCD; DICYCLOHADXYLCBODIDE
Imiti yimiti ya dicyclothexyllcarbodiimide
● Kugaragara / Ibara: Ibara ridafite ibara
. Umuvuduko mwinshi: 1.044-1.15pa saa 20-25 ℃
● Gushonga Ingingo: 34-35 ° C (Lit.)
Indangagaciro irohereza: N20 / D 1.48
Ingingo itetse: 277 ° C kuri 760 mmhg
Flash Ingingo: 113.1.1 ° C.
● Zab:24.72000
● Ubucucike: 1.06 G / CM3
● LogP: 3.82570
SHAKA TEMP.
.
.:Methylene chloride: 0.1 g / ml, isobanutse, idafite ibara
● Amazi yoroheje .:reaction
● XOGP3: 4.7
● Hydrogen Bond Abaterankunga kubara: 0
● Hydrogen Bond Kubara: 2
● Bond Kubara: 2
● Misa nyayo: 206.178298710
Atom Atom Arem: 15
● Ingorabahizi: 201
● Ikirango cyo gutwara abantu: Uburozi
Amakuru ya hefy
● Pictogram (s):
T,
Xn
Code ya Hazard: t, xn, t +
Imvugo: 23/8 / 25-34-400-43-41-36 / 38-24-22-6-27 / 38-10-8-20 / 22
Amakuru yumutekano: 26-36 / 37/2-45-41-24-37 / 39-24 / 25-36-16-53-28
Ingirakamaro
Amasomo ya Chimique:Azogen Ibice -> Ibindi bigo bya azoge
Inseko ya kanonical:C1CCC (CC1) N = C = NC2CCCCC2
Ibisobanuro:Dicydoushexyl Carbodiimide ikoreshwa muri chimie ya peptide nkumugozi uhuza. Numusazi numukangurambaga, kandi utera umubonano dermatitis muri farumasi na chimiste.
Ikoresha:Muri synthesis yo kuri buri gihe. Iki gicuruzwa gikoreshwa cyane muri amikagin, glutathione umwumva umwubaha, kimwe no muri synthesis ya aside anhydride, Aldehyde, Ketone, Isonenate; Iyo ikoreshwa nkuburaro bwumushyitsi, yitwara kuri diclyclohexyluro mukirubuga mugihe gito munsi yubushyuhe busanzwe. Iki gicuruzwa kirashobora kandi gukoreshwa muri synthesis ya peptide na aside iricleic. Biroroshye gukoresha iki gicuruzwa kugirango ubyare hamwe nibice bya Carboxy na Amino-itsinda muri peptide. Iki gicuruzwa gikoreshwa cyane mubuvuzi, ubuzima, gutora no kubinyabuzima nibinyabuzima, nizindi mirima ya synthetic. N, n'-dicyclopexylcarbodide ni carbodiimide yakundaga guhuza aside amine mugihe cya synthesis. N, n'-dicyclopexylcarbodide ikoreshwa nkumuntu unyuha kugirango ategure itumanaho, Ketones, Nitriles kimwe no kwikuramo inzoga za kabiri. DicyclopexylcarboDiimide ikoreshwa nkumuntu unyurwa mubushyuhe bwicyumba nyuma yigihe gito cyo gukora, nyuma yibicuruzwa byimyitwarire ni diclyclothexyexreea. Igicuruzwa ni gito cyane mubintu bya kama, kugirango gutandukana byoroshye nibicuruzwa.
Intangiriro irambuye
DicyclothexylcarboDiimage (DCC) ni reagent ikoreshwa muri synthesis kama. Nibibazo byera bidahujwe mumazi no gushonga mubintu bya kama nka rotyl acetate na dichloromethane.
DCC ikoreshwa cyane nkumukozi usanzwe muri synthesis hamwe nibindi bitekerezo birimo gushinga imishinga. Itezimbere congensnsiation acide ya karboxy Irabigeraho mugukora acide ya carboxy
Usibye Synthesis ya Peptide, DCC ikoreshwa no mubindi bikoresho bitandukanye, nko gushikama no kugabana. Irashobora gukoreshwa kugirango ikore ester acide ya Carbox
DCC izwiho gukora neza mugutezimbere ishyaka ryumubano kandi kubwuzuzanya nitsinda rinini. Ariko, bifatwa nkaho byunvikana cyane kandi birashobora kubora byoroshye kumazi cyangwa ubushuhe bukabije. Kubwibyo, mubisanzwe bikemurwa kandi bikabikwa munsi yuburyo budasanzwe.
Ni ngombwa gufata ingamba zikenewe mugihe ukorana na DCC, nkuko bishobora kurakaza uruhu, amaso, hamwe nubuhumekero. Guhumeka neza nibikoresho byo kurinda bigomba gukoreshwa mugihe cyo gufata.
Gusaba
DicyclopexxylcarboDiimage (DCC) ibona ikoreshwa zitandukanye muri synthesis kama, cyane cyane murwego rwa chimie ya peptide. Hano haribisabwa na DCC:
SynthesisDCC ikoreshwa nkumukozi usanzwe muri synthesis yo muri peptide kugirango yinjire aside amino hamwe kandi igahuza. Itezimbere resensetion ihuriye hagati yitsinda rya kanseri yitsinda rya aside imwe na amino irindi, riganisha ku gushishikarizwa.
Ibisubizo bya Erateri:DCC irashobora gukoreshwa muguhindura acride ya karbox muri esters tuyareba hamwe na alcool. Imbere ya DCC, aside iragati ya carboxy ikora, yemerera igitero cya nuclefilique ninzoga kugirango ikore ester. Iyi reaction ni ingirakamaro muri synthesis ya esters kubintu bitandukanye.
Ibitekerezo byo kumurimo:DCC irashobora koroshya medidation ya acide ya carboxy. Iremerera reaction hagati ya acide icide ya acide kandi amine kugirango ikore umurunga. Iyi porogaramu isanga ingirakamaro muri synthesis yo mu mwenda, ni ngombwa muri sisitemu zitandukanye y'ibinyabuzima na sinitique.
UI reaction:DCC irashobora gukoreshwa muri UGI, reaction nyinshi zirimo guhuza amine, igiteranyo cya Isocyana, kikangura karubone, na aside. DCC ifasha mugukora itsinda rya kanseri ya aside, kubikemerera kwitwara na amine kandi bikora imiyoboro.
Synthesis y'ibiyobyabwenge:DCC akenshi ikoreshwa mu nganda za farumasi muri synthesis yabakandida y'ibiyobyabwenge nibikoresho bifatika bya farumasi (APIS). Gukoresha muri synthesis ya peptide, mu biganiro, n'ibindi bisobanuro byingenzi bituma bigira regent yingenzi mu kuvumbura ibiyobyabwenge no guteza imbere iterambere.
Birakwiye ko tumenya ko DC ifite izindi porogaramu nyinshi muri synthesis ya kama, harimo gushiraho ures, kazoza, no kubeshya. Guhinduranya no guhuza nitsinda risanzwe rikora ryigikoresho cyingenzi mumashusho yisanduku ya chimiste ya synthetic.
