N-Methyl-2-pyrrolidone

Ibisobanuro bigufi:

Izina RY'IGICURUZWA:N-Methyl-2-pyrrolidone

Synonyme:M-PYROL (R); 1-Methyl-2-pyrrolidinone (99,5%, HyDry, Amazi 50 ppm (na KF)); ppm (by KF)); N-Methyl-2-pyrrolidone Ihingura; ACS); 1-Methyl-2-pyrrolidinone 872-50-4 NMP N-Methyl-2-pyrrolidinone; N-Methyl-2-pyrrolidinone 872-50-4 NMP; 1-METHYL-2-PYRROLIDINONE

URUBANZA:872-50-4

MF:C5H9NO

MW:99.13

EINECS:212-828-1

Ibyiciro by'ibicuruzwa:NMP; Ibikoresho fatizo bya shimi; UV / Vis); GC Umwanya wa GC; ICP-MS; Uburozi (usibye imiti yica udukoko / ibisigazwa by’ibiyobyabwenge); Porogaramu; Isesengura ry’ibinyobwa; Inzitizi zubaka; C4 kugeza C8; Synthesis ya chimique; ibiryo &; GC-MS Solvents; Ibice byubaka Heterocyclic; ICP-OES / -MS; Pyrrolidine; Reagents for Anorganic Trace Analysis; Solvents for Metal Speciation Analysis; Solvents for Analysis Speciation (LC-ICP-MS); Spectroscopy; Trace Analysis Reagents &; Anhydrous; Products; Amacupa ya Solvent; Amine; Heterocycle; Reagents zitandukanye; Anhydrous Solvents by Solvent by; Gusaba; Ingufu zindi; Amacupa yikirahure ya Amber; Isesengura ryisesengura; Isesengura / Chromatografiya; Umuti ukomoka kuri Organic; Semi-Bulk Solvents; Amacupa ya Solvent; Amahitamo yo gupakira; ; Nukuri / Ikidodo?Amacupa; 872-50-4; bc0001

Idosiye ya Mol:872-50-4.mol

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Ibicuruzwa birambuye

Ibicuruzwa

Imiti ya Pyrrolidone

Ingingo yo gushonga	-24 ° C (lit.)
Ingingo yo guteka	202 ° C (lit.) 81-82 ° C / 10 mmHg (lit.)
ubucucike	1.028 g / mL kuri 25 ° C (lit.)
ubucucike bw'umwuka	3.4 (vs ikirere)
umuvuduko w'umwuka	0,29 mm Hg (20 ° C)
indangagaciro	n20 / D 1.479
Fp	187 ° F.
ububiko bwa temp.	Ubike kuri + 5 ° C kugeza kuri + 30 ° C.
gukemura	Ethanol: ntibyumvikana0.1ML / mL, bisobanutse, bitagira ibara (10%, v / v)
ifishi	Amazi
pka	-0.41 ± 0.20 (Byahanuwe)
ibara	≤20 (APHA)
PH	8.5-10.0 (100g / l, H2O, 20 ℃)
Impumuro	Impumuro nziza ya amine
Urwego rwa PH	7.7 - 8.0
imipaka iturika	1.3-9.5% (V)
Amazi meza	> = 10 g / 100 mL kuri 20 ºC
Yumva	Hygroscopique
xmax	283nm (MeOH) (lit.)
Merk	14,6117
BRN	106420
Igihagararo:	Ihamye, ariko ibora iyo ihuye numucyo.Yaka.Ntibishobora gukoreshwa na okiside ikomeye, acide ikomeye, kugabanya ibintu, shingiro.
InChIKey	SECXISVLQFMRJM-UHFFFAOYSA-N
LogP	-0.46 kuri 25 ℃
CAS DataBase Reba	872-50-4 (CAS DataBase Reba)
Ubumenyi bwa NIST	2-Pyrrolidinone, 1-methyl- (872-50-4)
Sisitemu yo Kwiyandikisha Ibintu	N-Methyl-2-pyrrolidone (872-50-4)

Amakuru yumutekano

Kode ya Hazard	T, Xi
Ibisobanuro	45-65-36 / 38-36 / 37 / 38-61-10-46
Amatangazo yumutekano	41-45-53-62-26
WGK Ubudage	1
RTECS	UY5790000
F	3-8-10
Ubushyuhe bwa Autoignition	518 ° F.
TSCA	Y
Kode ya HS	2933199090
Ibintu Byangiza	872-50-4 (Ibyerekeye Ibintu Byangiza)
Uburozi	LD50 kumunwa murukwavu: 3598 mg / kg LD50 dermal Urukwavu 8000 mg / kg

Gukoresha Pyrrolidone Na Synthesis

Ibikoresho bya Shimi	N-Methyl-2-pyrrolidone ni ibara ritagira ibara ryumuhondo ryerurutse rifite impumuro nziza ya amoniya.N-Methyl-2-pyrrolidone ntishobora rwose n'amazi.Irashobora gushonga cyane muri alcool yo hepfo, ketone yo hepfo, ether, Ethyl acetate, chloroform, na benzene kandi igashonga kuburyo bugaragara muri hydrocarbone ya alifatique.N.Ifite imbaraga nke, imiti ikomeye nubushyuhe bwumuriro, polarite nyinshi, hamwe nihindagurika rito.Ibicuruzwa bifite uburozi buke, kandi byemewe kurenza urugero mu kirere ni 100ppm. N.
Gukoresha	N-Methyl-2-pyrrolidone (NMP) ni umusemburo wa polar aprotic ufite ibyiza byuburozi buke, ahantu hatetse cyane, ubwishyu budasanzwe, guhitamo gukomeye no guhagarara neza.Ikoreshwa cyane mugusukura hydrocarubone ya aromatic, acetylene, olefine, na diolefine. Ikoreshwa mugusukura inganda, kandi ikora nk'umusemburo wo gukora imiti yica udukoko, plastiki yubuhanga, ibifuniko, fibre synthique, hamwe nizunguruka. Irashobora kandi gukoreshwa nk'isuku mu nganda, ikwirakwiza, irangi, amavuta na antifreeze. N. Ikoreshwa mu gusohora gaze, gutunganya amavuta yo gutunganya, gusiga amavuta antifreeze, gukuramo olefin, no kuba igisubizo cyubwubatsi bwa plastike polymerisiyasi idashobora gushonga. Irashobora gukoreshwa mubyatsi byica ibyatsi, mugusukura ibikoresho byokwirinda, ibikoresho bya semiconductor inganda zisobanutse hamwe nu mbaho zumuzunguruko, gutunganya imyuka ya PVC, nkumuti wogosha, wongeyeho amarangi kandi ukwirakwiza. Ikoreshwa muburyo bwa polymerisation reaction nka plastiki yubuhanga na fibre aramid. N-Methyl-2-pyrrolidone ikoreshwa nka fluoride polyvinylidene fluoride hamwe nibikoresho bya electrode bifasha bateri ya lithium ion. urwego rwohejuru rwo kumenya ICP-MS. Kuri peptide.
uburozi	Umunwa (mus) LD50: 5130 mg / kg; Umunwa (imbeba) LD50: 3914 mg / kg; Dermal (rbt) LD50: 8000 mg / kg.
Kujugunya imyanda	Baza amabwiriza ya leta, ay'ibanze cyangwa ayigihugu kugirango ayakure neza.Kujugunya bigomba gukorwa hakurikijwe amabwiriza yemewe.Amazi, nibiba ngombwa hamwe nogusukura.
ububiko	N-Methyl-2-pyrrolidone ni hygroscopique (ifata ubuhehere) ariko ihagaze neza mubihe bisanzwe.Bizakora cyane hamwe na okiside ikomeye nka hydrogen peroxide, aside nitric, aside sulfurike, nibindi. Ibicuruzwa byangirika byambere bitanga imyuka ya karubone hamwe numwotsi wa azote.Kugaragara cyane cyangwa kumeneka bigomba kwirindwa nkikibazo cyimyitozo myiza.Uruganda rukora imiti rwa Lyondell rusaba kwambara uturindantoki twa butyl mugihe ukoresheje N-Methyl-2-pyrrolidone.N-Methyl-2-pyrrolidone igomba kubikwa mubyuma bisukuye, byoroheje bya fenolike byoroheje cyangwa ingoma zivanze.Teflon®1 na Kalrez®1 byagaragaye ko ari ibikoresho bya gaze.Nyamuneka suzuma MSDS mbere yo gukemura.
Ibisobanuro	N.Nubusanzwe birakaze, ariko kandi byateje inshuro nyinshi kwandura dermatite mumasosiyete mato ya electronique.
Ibikoresho bya Shimi	N-Methyl-2-pyrrolidone ni ibara ritagira ibara cyangwa ryijimye ry'umuhondo rifite umunuko wa amine.Irashobora guhura nimiti myinshi yimiti nubwo yemerwa nkigisubizo gihamye.Irwanya hydrolysis mubihe bidafite aho bibogamiye, ariko aside ikomeye cyangwa kuvura shingiro bivamo impeta gufungura aside-methyl aminobutyric 4.N-Methyl-2-pyrrolidone irashobora kugabanuka kugera kuri 1-methyl pyrrolidine hamwe na borohydride.Kuvura hamwe na chlorine ikora bivamo amide, intera irashobora gusimburwa, mugihe kuvura hamwe na nitrate ya amyl bitanga nitrate.Olefins irashobora kongerwaho kumwanya wa 3 mukuvura mbere hamwe na estal oxyde, hanyuma hamwe na aldehyes ikwiye (Hort na Anderson 1982).
Gukoresha	N-Methyl-2-pyrrolidone ni umusemburo wa polar ukoreshwa muri chimie organic na chimie polymer.Porogaramu nini zirimo kugarura no kweza acetylene, olefine, na diolefine, kweza gaze, no kuvoma aromatike mu bigega.N-Methyl-2-pyrrolidone ni inganda zitandukanye.NMP kuri ubu yemerewe gukoreshwa gusa muri farumasi yubuvuzi bwamatungo.Kumenya imyitwarire hamwe na metabolism ya NMP mu mbeba bizagira uruhare mu gusobanukirwa uburozi bw’iyi miti idasanzwe umuntu ashobora guhura nazo mu bwinshi.
Gukoresha	Umuti wubushyuhe bwo hejuru;gutunganya ibikomoka kuri peteroli, mu nganda zo guhimba mikorobe, amarangi n’ibara, inganda n’isuku mu ngo;ubuhinzi n’imiti
Gukoresha	N-Methyl-2-pyrrolidone, ni ingirakamaro kuri spekitifotometrie, chromatografiya no kumenya ICP-MS.
Ibisobanuro	ChEBI: Umunyamuryango wicyiciro cya pyrrolidine-2-ni pyrrolidine-2-imwe aho hydrogène ifatanye na azote isimburwa nitsinda rya methyl.
Uburyo bwo Kubyaza umusaruro	N-Methyl-2-pyrrolidone ikorwa nigisubizo cya buytrolactone hamwe na methylamine (Hawley 1977).Ibindi bikorwa birimo gutegura hydrogenation yumuti wa acide ya manic cyangwa succinic hamwe na methylamine (Hort na Anderson 1982).Abakora iyi miti barimo Lachat Chemical, Inc, Mequon, Wisconsin na GAF Corporation, Covert City, California.
Synthesis Reba (s)	Amabaruwa ya Tetrahedron, 24, p.1323, 1983DOI: 10.1016 / S0040-4039 (00) 81646-9
Ibisobanuro rusange	N-Methyl-2-Pyrrolidone (NMP) ni imbaraga zikomeye, zidasanzwe za aprotic zifite imbaraga nyinshi, hamwe n’umuvuduko muke.Iri bara ridafite ibara, ritetse cyane, flash point nini hamwe numuvuduko ukabije wumuyaga utwara impumuro nziza ya amine.NMP ifite imiti myinshi nubushyuhe bwumuriro kandi ntishobora kumvikana namazi mubushyuhe bwose.NMP irashobora gukora nk'amazi hamwe n'amazi, alcool, ethers ya glycol, ketone, hamwe na hydrocarbone ya aromatic / chlorine.NMP byombi bisubirwamo na distillation kandi byoroshye biodegradable.NMP ntabwo iboneka kurutonde rw’ibyuka bihumanya ikirere (HAPs) byahinduwe mu itegeko ryo mu 1990 ryahinduwe neza.
Umwuka & Amazi	Kubora mumazi.
Umwirondoro wa reaction	Iyi amine ni ishingiro ryimiti yoroheje cyane.N-Methyl-2-pyrrolidone ikunda guhindura aside kugirango ibe umunyu wongeyeho amazi.Ingano yubushyuhe ihindagurika kuri mole ya amine mukutabogama ahanini ntigengwa nimbaraga za amine nkibanze.Amine irashobora kutabangikanya na isocyanates, ibinyabuzima bya halogene, peroxide, fenolike (acide), epoxide, anhydride, na aside aside.Hydrogen hydrogène yaka umuriro ikorwa na amine ifatanije ningingo zikomeye zigabanya, nka hydride.
Hazard	Uruhu rukabije n'amaso arakara.Ibisasu biturika-2.2–12.2%.
Ubuzima	Guhumeka imyuka ishyushye irashobora kurakaza izuru n'umuhogo.Kuribwa bitera kurakara mu kanwa no mu gifu.Guhura n'amaso bitera uburakari.Guhuza uruhu inshuro nyinshi kandi birebire bitanga uburakari bworoheje, bwigihe gito.
Fire Hazard	Ibyago bidasanzwe byibicuruzwa byaka: Okiside yubumara ya azote irashobora gukorwa mumuriro.
Gutwikwa no guturika	Ntibishobora gutwikwa
Gukoresha inganda	1) N-Methyl-2-pyrrolidone ikoreshwa nkibisanzwe muri dipolar aprotic solvent, ihamye kandi idakora; 2) gukuramo hydrocarbone ya aromatiya mumavuta yo gusiga; 3) gukuramo karuboni ya dioxyde de generator ya ammonia; 4) nkigisubizo cya polymerisation reaction na polymers; 5) nk'umurangi w'irangi; 6) kumiti yica udukoko (USEPA 1985). Ubundi buryo budakoreshwa mu nganda bwa N-Methyl-2-pyrrolidone bushingiye ku miterere yabwo nk'umuti utandukanya ukwiranye n’ubushakashatsi bw’amashanyarazi n’umubiri (Langan na Salman 1987).Porogaramu ya farumasi ikoresha imiterere ya N-Methyl-2-pyrrolidone nk'iyongerera imbaraga zo kwinjiza ibintu vuba binyuze mu ruhu (Kydoniieus 1987; Barry na Bennett 1987; Akhter na Barry 1987).N-Methyl-2-pyrrolidone yemejwe nkigisubizo cyo gukoresha slimicide ikoreshwa mubikoresho byo gupakira ibiryo (USDA 1986).
Menyesha allergens	N.Ahanini birakaze, ariko birashobora gutera dermatite ikabije kubera guhura igihe kirekire.
Umwirondoro wumutekano	Uburozi n'inzira zinjira.Muburozi buringaniye nukunywa n'inzira za intraperitoneal.Uburozi bworoheje ukoresheje uruhu.Ubushakashatsi bwa teratogen.Ingaruka yimyororokere yubushakashatsi.Amakuru ya mutation yatangajwe.Yaka iyo ihuye nubushyuhe, urumuri rufunguye, cyangwa okiside ikomeye.Kurwanya umuriro, koresha ifuro, CO2, imiti yumye.Iyo ishyutswe kugirango ibore isohora imyotsi yuburozi ya NOx.
Kanseri	Imbeba zagaragaye kuri N-Methyl-2-pyrrolidone ziva kuri 0, 0.04, cyangwa 0.4 mg / L kumasaha 6 h / kumunsi, iminsi 5 / icyumweru kumyaka 2. Imbeba zumugabo kuri 0.4 mg / L zerekanye ko zigabanutseho gato bivuze uburemere bwumubiri.Nta ngaruka zigabanya ubuzima bw’ubumara cyangwa kanseri zagaragaye mu mbeba zagaragaye mu myaka 2 kugeza kuri 0.04 cyangwa 0.4mg / L ya N-Methyl-2-pyrrolidone.Binyuze mu nzira ya dermal, itsinda ryimbeba 32 zabonye urugero rwo gutangiza 25mg ya N-Methyl-2-pyrrolidone yakurikiranye nyuma yibyumweru 2 hakoreshejwe uburyo bwo gutera ibibyimba bitera ibibyimba phorbol myristate acetate, gatatu mu cyumweru, ibyumweru birenga 25.Dimethylcarbamoyl chloride na dimethylbenzanthracene byabaye nk'igenzura ryiza.Nubwo itsinda rya N-Methyl-2-pyrrolidone ryagize ibibyimba bitatu byuruhu, iki gisubizo nticyigeze gifatwa nkicyiza ugereranije nubushakashatsi bwiza.
Inzira ya metabolike	Imbeba zitangwa na radiyo yanditseho N-methyl-2- pyrrolidinone (NMP), kandi inzira nyamukuru yo gusohoka n'imbeba ni kunyura mu nkari.Metabolite nyamukuru, igereranya 70-75% yumuti watanzwe, ni 4- (methylamino) acide ya butenoic.Iki gicuruzwa kidahagije gishobora gushingwa kuva kurandura amazi, kandi itsinda rya hydroxyl rishobora kuba kuri metabolite mbere ya hydrolysis ya aside.
Metabolism	Imbeba za Sprague-Dawley zahawe inshinge imwe ya intraperitoneal (45 mg / kg) ya radiolabel 1 -methyl-2-pyrrolidone.Urwego rwa plasma rwa radioactivite hamwe nuruvange rwakurikiranwe amasaha atandatu kandi ibisubizo byatanze icyiciro cyo gukwirakwiza byihuse bikurikirwa nicyiciro cyo kurandura buhoro.Umubare munini wibirango wasohotse mu nkari mu masaha 12 kandi bingana na 75% bya dose yanditseho.Nyuma yamasaha makumyabiri nane nyuma ya dosiye, gusohora cumulative (inkari) byari hafi 80% byimiti.Byombi byakoreshejwe impeta- na methyl byanditseho, kimwe byombi [¹⁴C] - na [3H] -yanditseho l-methyl-2-pyrrolidone.Ikigereranyo cyambere cyanditse cyagumishijwe mugihe cyamasaha 6 yambere nyuma ya dosiye.Nyuma yamasaha 6, umwijima n amara wasangaga birimo ibintu byinshi bya radioactivite, hafi 2-4% bya dose.Iradiyo ntoya yagaragaye mu mara cyangwa mu mwuka uhumeka.Imikorere ihanitse ya chromatografi yinkari yerekanaga ko hariho metabolite imwe nini na ebyiri nto.Metabolite nini (70-75% yumuti wa radio ikoreshwa) yasesenguwe na chromatografiya yamazi-mass spectrometrie na gazi chromatografiya-mass spectrometrie hanyuma isabwa kuba 3- cyangwa 5-hydroxy-l-methyl-2-pyrrolidone (Iriba 1987).
Uburyo bwo kweza	Kama pyrrolidone ukuramo amazi nka * benzene azeotrope.Gucamo ibice kuri torr 10 unyuze kumurongo wa cm 100 wuzuye ibirahuri.[Adelman J Org Chem 29 1837 1964, McElvain & Vozza J Am Chem Soc 71 896 1949.] Hydrochloride ifite m 86-88o (kuva EtOH cyangwa Me2CO / EtOH) [Reppe et al.Justus Liebigs Ann Chem 596 1 1955].[Beilstein 21 II 213, 21 III / IV 3145, 21/6 V 321.]