Ibicuruzwa
Pymuridine-2,4 (1h, 3h) -dione; CYA No 66-22-8
Synonyme: Ural
Umutungo wa shimi wa pynidine-2,4 (1h, 3h) -dione
● Kugaragara / ibara: ifu yera
Cyiza Cyiza: 2.27E-08mhhg kuri 25 ° C.
● Gushonga Ingingo:> 300 ° C (Lit.)
Indangagaciro iroba: 1.501
Ingingo yo guteka: 440.5 ° C kuri 760 mmhg
● PKA: 9.45 (kuri 25 ℃)
● Flash Ingingo: 220.OC
● Zab:65.72000
● Ubucucike: 1.322 G / CM3
● LogP: -0.93680
. Ububiko Temp.:+15c Kuri + 30c
.:OUBALT
● Amazi yoroheje. Arnosox mumazi ashyushye
● Xlogp3: -1.1
● Hydrogen Bond Abaterankunga kubara: 2
● Hydrogen Bond Kubara: 2
● Bond Kubara: 0
● Misa nyayo: 112.027277375
Atom Atom Kubara: 8
Kugorana: 161
Amakuru ya hefy
● Pictogram (s):
Xi
Kode ya Hazard: xi
● Amagambo y'umutekano: 22-24 / 25
Ingirakamaro
Amasomo ya Chimique:Abakozi bo mu binyabuzima -> acide nocleic n'ibikomoka
Inseko ya kanonical:C1 = CNC (= o) NC1 = o
Clinicaltrials vuba:Kwiga 0.1% Uracikere cream (UTC) kugirango wirinde syndrome yamaguru
Ibigeragezo bya EU ya vuba:Ondentoek Naar de Farmacokotinetiek Van na Orale Toediening Bij Pati? Nten yahuye na karcinoom.
Ibigeragezo bya Niph biherutse kuvugwa: Icyiciro cya PHASE II RY'UBUYOBOZI BWA KURAULLIATICI KUBURYO BURUNDURWA CYA CAPECITAbine itera Syndrome y'Ubutarenge mu ntoki (HFS):.
Ikoresha:Kubishakashatsi bwibinyabuzima, synthesis yibiyobyabwenge; gukoreshwa nkibintu byimiti ya farumasi, nabyo bikoreshwa muri synthesi ya kama na synthesious on nucleosides ya RNA. antineoplastique ubushakashatsi bwibinyabuzima. Ural (Lamivudine EP Imyandamubiri f) ni ishingiro rya aterodeous kuri RNE &
Ibisobanuro:Ural ni pymuridine shingiro hamwe nigice cyibanze cya rna aho bihuza adenine ukoresheje hydrogen. Yahinduwe mucleoside utleoh unyuze kuri Moint Moie, hanyuma kuri uridine uricleotide uridine monophosphate hiyongereyeho itsinda rya fosifate.
Intangiriro irambuye
Ural ni igikona kama cya mu muryango wa Pynidite. Ni molecule ya heteroquetike igizwe nimpeta ya pynidine hamwe na atome zituranye za azome. Ural ifite imiti C4h4n2o2 nuburemere bwa molekile bwa 112.09 g / mol.
Ural nimwe muri ane nucleobase ziboneka mubikoresho bya genetike ya RNA (acide riboncleic). Ifite uruhare rukomeye muri Synthesis na Gene. Muri RNA, Urall hamwe na Adenine ukoresheje amazu y'amazi, bikora ibitsina bibiri, kandi iyi shingiro fatizo bifasha kwinjiza amakuru ya genetike.
Uracil arashobora kandi kuboneka mubindi molekile yingenzi yibinyabuzima. Kurugero, nikintu cyingenzi cya molekile itwara ingufu zitwa ATP (Adenosine Triphosphate). Ibikomoka kuri Ural, nka 5-fluerouracil, byakoreshejwe nk'abakozi bashinzwe kurwanya kubera ubushobozi bwabo bwo kwivanga hamwe no kwigana kwa ADN no kugabana karuri.
Usibye ubusobanuro bwibinyabuzima, Ural ifite porogaramu zitandukanye za shimi n'inganda. Ikoreshwa nkibikoresho byo gutangira kuri synthesis ya farumasi, agrochemicals, na dyes. Ibikomoka kuri Ural na byo bikoreshwa mugukora ibyatsi na fungicide. Byongeye kandi, Ural arashobora gukoreshwa nkigishushanyo muri chimie yisesengura kandi nkigikoresho mubikorwa bya molekili.
Ural ni ikirahuri cyera kitoroshye kidakunzwe mumazi. Birahamye mubihe bisanzwe ariko birashobora gukoreshwa imiti, nko kuri okiside no kusimburwa ibitekerezo, mubihe byihariye. Ibigo bifite aho bishonga 335-338°C hamwe ningingo itetse ya 351-357°C.
Muri rusange, Urall nikintu cyingenzi mubikorwa bifatika bya RNA kandi bifite ibyifuzo byingenzi mubinyabuzima nubushyuhe.
Gusaba
Ural afite ibyifuzo byinshi mumirima itandukanye, harimo:
Inganda za farumasi:Ural hamwe nibibi byayo byakoreshejwe mugutegura ibiyobyabwenge kubikorwa bitandukanye. Kurugero, 5-Fluorouracil ni ibiyobyabwenge bikunze gukoreshwa kugirango byovure indwara zimwe na zimwe. Ibiyobyabwenge bishingiye ku gishira bya murali, nka Idoxuridine na Trifluritine, bikoreshwa mu kuvura indwara zanduye.
Ubuhinzi:Ibikomoka kuri Ural bikoreshwa mugukora ibyatsi na fungicide. Ibi bikoresho bifasha kugenzura imikurire yibyatsi kandi birinda ibihingwa biva mu kwanduza.
Chimie yisesengura:Uracirwa akunze gukoreshwa nka marike ya chromatografi cyangwa urwego rwimbere muburyo bwo gusesengura chimie. Irashobora gukoreshwa nkikigereranyo kijyanye no kumenya igihe cyo kuguruka no kubahiriza ibindi bigize kurugero.
Ubushakashatsi bwa MolekoriUracirwa muburyo butandukanye bwibinyabuzima bubi, nka Polymeyese reaction (PCR), ADN ikurikiranye, hamwe na mutaruSnesis. Ikora nk'icyitegererezo cya synthesis ya ADN cyangwa nk'ibigizemo uruhare mu gushyiraho ihinduka ry'imiterere ya ADN.
Inganda zibiribwa:Uracirwa rimwe na rimwe ukoreshwa nkubusa mu nganda zibiribwa, cyane cyane mugukora ibiryo bitunganijwe nibinyobwa.
Kwisiga:Ibikomoka kuri Ural bikoreshwa mubicuruzwa byo kwisiga kugirango bibe byiza kandi bihumure uruhu. Bashobora gufasha kunoza urukundo no kurengera imihangayiko y'ibidukikije.
Ubushakashatsi n'iterambere:Ural kandi ukoreshwa mubinyabuzima nubushakashatsi bwa farumasi nkigitekerezo cyangwa hagati yo guhuza ibindi bikorwa hamwe nibinyabuzima cyangwa kwiga aside nucleic metabolism.
URAIG yashinze ikoreshwa yerekana akamaro kayo mu mirima nkubuvuzi, ubuhinzi, chimie, na biotechnology. Abashakashatsi bakomeje gushakisha uburyo bushya bwo gukoresha imitungo yayo kugira ngo hajyaho iterambere muri utwo turere.
